CODEN : IJPNL 6 Formulation and evaluation of bilayered floating tablets of cefuroxime axetil

Study aims to design a Gastro retentive Drug Delivery System of Cefuroxime axetil (CA). CA is a broad spectrum beta lactam type of antibiotic. More specifically, it is a second-generation cephalosporin. CA has site specific absorption from upper gastro intestinal tract and in intestine it undergoes hydrolysis to cefuroxime having poor absorption. Unabsorbed drug causes high concentration of antibiotic entering into colon and contributes to side effects colitis. Therefore a gastro-retentive drug delivery system is required to ensure controlled drug delivery within drug absorbable region. Bilayer tablet, each layer containing half the dose of the drug was formulated with Immediate Release Layer (IRL) and Floating Matrix Layer (FML). The present research describes formulation of bilayered floating tablets of Cefuroxime axetil using HPMC polymers like HPMC K4M, HPMC K15M, HPMC K100M and Sodium alginate. All formulations showed acceptable specifications for weight variation, thickness, hardness and friability. The formulations containing HPMC K4M, HPMC K15M provides a better option for Controlled release than HPMC K100M and Sodium alginate.